NANOPLEX™ biomarker detection
These silica-coated, surface enhanced Raman scattering (SERS)-active metal nanoparticles allow robust, ultrasensitive, highly-multiplexed biomarker quantitation in any biological matrix, including whole blood.
Click here to view NANOPLEX biomarker formation animationThe NANOPLEX™ technology, comprising portable readers, software, nanoparticles, and conjugation protocols, allows high-performance, multiplexed assays to be developed for immunodiagnostics, molecular diagnostics, and proteomics, in a wide range of formats, from disposable, rapid lateral flow tests to highly innovative assay formats for near patient and hospital lab testing , to high-throughput multi-well screens.
Advantages to the technology include:
- High-level multiplexing and simultaneous internal calibration
- Minimal, interference from highly-coloured and/or scattering samples such as blood or fixed tissue, as well as from consumable materials such as polypropylene, nitrocellulose, etc. through near-infrared excitation and detection
- Environment-insensitive signal generation, and simple biofunctionalization through a silica (glass) coating
Together, these benefits translate to unprecedented capabilities for biomarker quantitation, with the ability to support the implementation of the next generation of ultra-sensitive, multiplexed biomarkers, covering a wide range of areas, from infectious disease, cardiac and cancer diagnostics to food testing for pathogens and animal health.
Oxonica Healthcare is based in our Mountain View facility, California, USA.
Publications on the Nanoplex™ biotag Technology
- Sha et al., “Detection of Human Viral RNA via a Combined Fluorescence and SERS Molecular Beacon Assay”, Nanobiotechnology, 2007, epublish ahead of online.
- M. J. Natan, “Surface enhanced Raman scattering”, Faraday Discuss. 2006, 132, 321-328.
- Freeman et al. “Detection of biomolecules using nanoparticle surface enhanced Raman scattering tags” Proceedings of SPIE Vol. 5705. Nanobiophotonics and Biomedical Applications II, Alexander N. Cartwright; Marek Osinski, Editors, pp.114-122, 28 April 2005.
- Young et al. “Nanomolecular histopathology for renal tumor classification” Conf. Proc IEEE Eng Med Biol Soc, 2005, 1, 723-726.
- Mulvaney, et al., “Glass-Coated, Analyte-Tagged Nanoparticles: A New Tagging System Based on Detection with Surface-Enhanced Raman Scattering”, Langmuir, 2003, 19, 4784-90.
- Penn et al., “Nanoparticles for bioanalysis”, Current Opinions in Chemical Biology, 2003, 7, 609-615